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2025Nature

The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies

Kyle Swanson, Wesley Wu, Nash L. Bulaong et al.

What this work does

A principal-investigator agent coordinates specialized scientist/critic agents through meetings, producing a computational nanobody design pipeline with human guidance.

Connection to discovery

A real experimental-validation case for distinguishing proposal generation, computational scoring and physical evidence.

Evidence

Inspected pipeline scoring, experimental binding discussion and the statement that humans executed scripts and contributed infrastructure code.

Scope and limitations

The word virtual describes the agent team, not the entire evidence source. Human execution and wet-lab work remain substantial; binding assays are not clinical efficacy. The journal PDF was downloaded from an academic teaching mirror after the publisher PDF endpoint failed.

THE RESEARCH CONVERSATION

Discussion & reactions

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